Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Bench-to-bedside review: contrast enhanced ultrasonography--a promising technique to assess renal perfusion in the ICU.
Critical Care (london, England)
Publication types: Journal Article ; Review Publication Status: ppublish
Acute kidney injury (AKI) is common in critically ill patients and associated with important morbidity and mortality. Although alterations in renal perfusion are thought to play a causative role in the pathogenesis of AKI, there is, to date, no reliable technique that allows the assessment of renal perfusion that is applicable in the ICU. Contrast-enhanced ultrasound (CEUS) is an ultrasound imaging technique that makes use of microbubble-based contrast agents. These microbubbles, when injected into the bloodstream, allow visualization of vascular structures and, with contrast-specific imaging modes, detection of blood flow at the capillary level. Some recent CEUS-derived approaches allow quantification of blood flow in several organs, including the kidney. Current generation ultrasound contrast agents have strong stability and safety profiles. Along with post-marketing surveillance, numerous studies report safe administration of these agents, including in critically ill patients. This review presents information on the physical principles underlying CEUS, the methods allowing blood flow quantification and the potential applications of CEUS in critical care nephrology, currently as a research tool but perhaps in the future as a way of monitoring renal perfusion.
Acute Kidney Injury/physiopathology, Acute Kidney Injury/ultrasonography, Animals, Contrast Media/diagnostic use, Humans, Intensive Care Units/trends, Kidney/blood supply, Kidney/ultrasonography, Microbubbles/diagnostic use, Point-of-Care Systems/trends
Web of science
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