Perchance to dream: solving the mystery of sleep through genetic analysis.

Details

Serval ID
serval:BIB_11110B656DE4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Perchance to dream: solving the mystery of sleep through genetic analysis.
Journal
Journal of Neurobiology
Author(s)
Shaw P.J., Franken P.
ISSN
0022-3034[print], 0022-3034[linking]
Publication state
Published
Issued date
2003
Volume
54
Number
1
Pages
179-202
Language
english
Abstract
Sleep has been identified in all mammals and nonmammalian vertebrates that have been critically evaluated. In addition, sleep-like states have also been identified and described in several invertebrates. Despite this prevalence throughout the animal kingdom, the function of sleep remains a mystery. The completion of several genome sequencing projects has led to the expectation that fundamental aspects of sleep can be elucidated through genetic dissection. Indeed, studies in both the mouse and fly have begun to reveal tantalizing suggestions about the underlying principles that regulate sleep homeostasis. In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse.
Keywords
Animals, Animals, Inbred Strains, Chromosome Mapping, Circadian Rhythm/genetics, Circadian Rhythm/physiology, Dreams/physiology, Drosophila melanogaster, Electroencephalography, Gene Expression Regulation, Genetic Techniques, Homeostasis/genetics, Homeostasis/physiology, Mice, Phenotype, Quantitative Trait Loci, Sleep/genetics, Sleep/physiology, Sleep Deprivation/genetics, Sleep Deprivation/physiopathology, Sleep, REM/genetics, Sleep, REM/physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:31
Last modification date
20/08/2019 12:38
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