Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]

Details

Serval ID
serval:BIB_0F86F7A2FE73
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]
Journal
Annales de pathologie
Author(s)
Trimeche M., Ziadi S., De Leval L., Hmissa S., Sriha B., Mokni M., Toumi I., Elomri H., Laatiri A., Kehlif A., Boniver J., Korbi S.
ISSN
0242-6498 (Print)
ISSN-L
0242-6498
Publication state
Published
Issued date
04/2005
Peer-reviewed
Oui
Volume
25
Number
2
Pages
95-102
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
The purpose of this study was to evaluate the prevalence of EBV in non-Hodgkin's lymphomas occuring in non-immunocopromised patients in Tunisia through a series of 126 cases. EBV was investigated by EBER oligonucleotide in situ hybridization (ISH) and LMP1-immunohistochemistry. Serological study of EBV has been performed before therapy in 28 patients. EBV was detected in tumor cells by ISH in 28/126 (22.2%) cases. Variable proportions of tumor cells were positive. LMP1 was identified in only 8 cases. EBV was more frequently observed in T-cell lymphomas (9/24 patients; 37.5%) than in B-cell lymphomas (19/102 patients; 18.6%) (p=0.04). There was a strong relationship between EBV and small intestine lymphomas (6/8 patients; 75%) and T/NK nasal type lymphomas (3/3 patients; 100%). EBV serological reactivation was noted in 7/13 patients in clinical stages III/IV and in only 1/10 patients in stages I/II (p=0.03). In conclusion, the prevalence of EBV in Tunisian non-Hodgkin's lymphomas is low but variable depending on the histological type and anatomical location with a predilection for small intestine and nasal lymphomas.
Keywords
Epstein-Barr Virus Infections/epidemiology, Geography, Herpesvirus 4, Human/genetics, Herpesvirus 4, Human/isolation & purification, Humans, In Situ Hybridization, Lymphoma, Non-Hodgkin/epidemiology, Lymphoma, Non-Hodgkin/virology, Prevalence, Tunisia/epidemiology
Pubmed
Web of science
Create date
28/10/2010 9:39
Last modification date
17/10/2023 9:57
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