Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]

Détails

ID Serval
serval:BIB_0F86F7A2FE73
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]
Périodique
Annales de pathologie
Auteur⸱e⸱s
Trimeche M., Ziadi S., De Leval L., Hmissa S., Sriha B., Mokni M., Toumi I., Elomri H., Laatiri A., Kehlif A., Boniver J., Korbi S.
ISSN
0242-6498 (Print)
ISSN-L
0242-6498
Statut éditorial
Publié
Date de publication
04/2005
Peer-reviewed
Oui
Volume
25
Numéro
2
Pages
95-102
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Résumé
The purpose of this study was to evaluate the prevalence of EBV in non-Hodgkin's lymphomas occuring in non-immunocopromised patients in Tunisia through a series of 126 cases. EBV was investigated by EBER oligonucleotide in situ hybridization (ISH) and LMP1-immunohistochemistry. Serological study of EBV has been performed before therapy in 28 patients. EBV was detected in tumor cells by ISH in 28/126 (22.2%) cases. Variable proportions of tumor cells were positive. LMP1 was identified in only 8 cases. EBV was more frequently observed in T-cell lymphomas (9/24 patients; 37.5%) than in B-cell lymphomas (19/102 patients; 18.6%) (p=0.04). There was a strong relationship between EBV and small intestine lymphomas (6/8 patients; 75%) and T/NK nasal type lymphomas (3/3 patients; 100%). EBV serological reactivation was noted in 7/13 patients in clinical stages III/IV and in only 1/10 patients in stages I/II (p=0.03). In conclusion, the prevalence of EBV in Tunisian non-Hodgkin's lymphomas is low but variable depending on the histological type and anatomical location with a predilection for small intestine and nasal lymphomas.
Mots-clé
Epstein-Barr Virus Infections/epidemiology, Geography, Herpesvirus 4, Human/genetics, Herpesvirus 4, Human/isolation & purification, Humans, In Situ Hybridization, Lymphoma, Non-Hodgkin/epidemiology, Lymphoma, Non-Hodgkin/virology, Prevalence, Tunisia/epidemiology
Pubmed
Web of science
Création de la notice
28/10/2010 9:39
Dernière modification de la notice
17/10/2023 9:57
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