Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]
Détails
ID Serval
serval:BIB_0F86F7A2FE73
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prévalence du virus d'Epstein-Barr dans les lymphomes non hodgkiniens dans la région du Centre Tunisien [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia]
Périodique
Annales de pathologie
ISSN
0242-6498 (Print)
ISSN-L
0242-6498
Statut éditorial
Publié
Date de publication
04/2005
Peer-reviewed
Oui
Volume
25
Numéro
2
Pages
95-102
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The purpose of this study was to evaluate the prevalence of EBV in non-Hodgkin's lymphomas occuring in non-immunocopromised patients in Tunisia through a series of 126 cases. EBV was investigated by EBER oligonucleotide in situ hybridization (ISH) and LMP1-immunohistochemistry. Serological study of EBV has been performed before therapy in 28 patients. EBV was detected in tumor cells by ISH in 28/126 (22.2%) cases. Variable proportions of tumor cells were positive. LMP1 was identified in only 8 cases. EBV was more frequently observed in T-cell lymphomas (9/24 patients; 37.5%) than in B-cell lymphomas (19/102 patients; 18.6%) (p=0.04). There was a strong relationship between EBV and small intestine lymphomas (6/8 patients; 75%) and T/NK nasal type lymphomas (3/3 patients; 100%). EBV serological reactivation was noted in 7/13 patients in clinical stages III/IV and in only 1/10 patients in stages I/II (p=0.03). In conclusion, the prevalence of EBV in Tunisian non-Hodgkin's lymphomas is low but variable depending on the histological type and anatomical location with a predilection for small intestine and nasal lymphomas.
Mots-clé
Epstein-Barr Virus Infections/epidemiology, Geography, Herpesvirus 4, Human/genetics, Herpesvirus 4, Human/isolation & purification, Humans, In Situ Hybridization, Lymphoma, Non-Hodgkin/epidemiology, Lymphoma, Non-Hodgkin/virology, Prevalence, Tunisia/epidemiology
Pubmed
Web of science
Création de la notice
28/10/2010 9:39
Dernière modification de la notice
17/10/2023 9:57