Article: article from journal or magazin.
Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.
Journal of Neuroimmunology
Publication types: Journal Article Publication Status: ppublish
Little is known on a putative effect of vitamin D on CD8+ T cells. Yet, these cells are involved in the immmunopathogenesis of MS. We assessed the cytokine profile of EBV-specific CD8+ T cells of 10 early MS patients and 10 healthy control subjects with or without 1,25(OH)(2)D(3) and found that, with 1,25(OH)(2)D(3), these cells secreted less IFN-γ and TNF-α and more IL-5 and TGF-β. CD4+ T cell depletion or even culture with CD8+ T cells only did not abolish the immunomodulatory effect of 1,25(OH)(2)D(3) on CD8+ T cells, suggesting that 1,25(OH)(2)D(3) can act directly on CD8+ T cells.
Adult, Antigens, CD/metabolism, Cytokines/genetics, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/immunology, Female, Flow Cytometry, Gene Expression Regulation, Viral/physiology, Herpesvirus 4, Human, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Multiple Sclerosis/pathology, Pilot Projects, RNA, Messenger/metabolism, Statistics, Nonparametric, T-Lymphocytes/immunology, T-Lymphocytes/virology
Web of science
Last modification date