Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.

Détails

ID Serval
serval:BIB_0F1F4FF4D30A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.
Périodique
Journal of Neuroimmunology
Auteur(s)
Lysandropoulos A.P., Jaquiéry E., Jilek S., Pantaleo G., Schluep M., Du Pasquier R.A.
ISSN
1872-8421 (Electronic)
ISSN-L
0165-5728
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
233
Numéro
1-2
Pages
240-244
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Little is known on a putative effect of vitamin D on CD8+ T cells. Yet, these cells are involved in the immmunopathogenesis of MS. We assessed the cytokine profile of EBV-specific CD8+ T cells of 10 early MS patients and 10 healthy control subjects with or without 1,25(OH)(2)D(3) and found that, with 1,25(OH)(2)D(3), these cells secreted less IFN-γ and TNF-α and more IL-5 and TGF-β. CD4+ T cell depletion or even culture with CD8+ T cells only did not abolish the immunomodulatory effect of 1,25(OH)(2)D(3) on CD8+ T cells, suggesting that 1,25(OH)(2)D(3) can act directly on CD8+ T cells.
Mots-clé
Adult, Antigens, CD/metabolism, Cytokines/genetics, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/immunology, Female, Flow Cytometry, Gene Expression Regulation, Viral/physiology, Herpesvirus 4, Human, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Multiple Sclerosis/pathology, Pilot Projects, RNA, Messenger/metabolism, Statistics, Nonparametric, T-Lymphocytes/immunology, T-Lymphocytes/virology
Pubmed
Web of science
Création de la notice
04/01/2011 18:01
Dernière modification de la notice
20/08/2019 13:35
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