Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.

Details

Serval ID
serval:BIB_0F1F4FF4D30A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects.
Journal
Journal of Neuroimmunology
Author(s)
Lysandropoulos A.P., Jaquiéry E., Jilek S., Pantaleo G., Schluep M., Du Pasquier R.A.
ISSN
1872-8421 (Electronic)
ISSN-L
0165-5728
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
233
Number
1-2
Pages
240-244
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Little is known on a putative effect of vitamin D on CD8+ T cells. Yet, these cells are involved in the immmunopathogenesis of MS. We assessed the cytokine profile of EBV-specific CD8+ T cells of 10 early MS patients and 10 healthy control subjects with or without 1,25(OH)(2)D(3) and found that, with 1,25(OH)(2)D(3), these cells secreted less IFN-γ and TNF-α and more IL-5 and TGF-β. CD4+ T cell depletion or even culture with CD8+ T cells only did not abolish the immunomodulatory effect of 1,25(OH)(2)D(3) on CD8+ T cells, suggesting that 1,25(OH)(2)D(3) can act directly on CD8+ T cells.
Keywords
Adult, Antigens, CD/metabolism, Cytokines/genetics, Cytokines/metabolism, Enzyme-Linked Immunosorbent Assay/methods, Epstein-Barr Virus Infections/immunology, Female, Flow Cytometry, Gene Expression Regulation, Viral/physiology, Herpesvirus 4, Human, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Multiple Sclerosis/pathology, Pilot Projects, RNA, Messenger/metabolism, Statistics, Nonparametric, T-Lymphocytes/immunology, T-Lymphocytes/virology
Pubmed
Web of science
Create date
04/01/2011 17:01
Last modification date
20/08/2019 12:35
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