Occupational asthma: new low-molecular-weight causal agents, 2000-2010

Details

Serval ID
serval:BIB_0BE394E73434
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Occupational asthma: new low-molecular-weight causal agents, 2000-2010
Journal
Journal of Allergy
Author(s)
Pralong Jacques A., Cartier André, Vandenplas Olivier, Labrecque Manon
ISSN
1687-9791 (Electronic)
ISSN-L
1687-9783
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
2012
Pages
597306
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Background. More than 400 agents have been documented as causing occupational asthma (OA). The list of low-molecular-weight (LMW) agents that have been identified as potential causes of OA is constantly expanding, emphasizing the need to continually update our knowledge by reviewing the literature. Objective. The objective of this paper was to identify all new LMW agents causing occupational asthma reported during the period 2000-2010. Methods. A Medline search was performed using the keywords occupational asthma, new allergens, new causes, and low-molecular-weight agents. Results. We found 39 publications describing 41 new LMW causal agents, which belonged to the following categories: drugs (n = 12), wood dust (n = 11), chemicals (n = 8), metals (n = 4), biocides (n = 3), and miscellaneous (n = 3). The diagnosis of OA was confirmed through SIC for 35 of 41 agents, peak expiratory flow monitoring for three (3) agents, and the clinical history alone for three (3) agents. Immunological tests provided evidence supporting an IgE-mediated mechanism for eight (8) (20%) of the newly described agents. Conclusion. This paper highlights the importance of being alert to the occurrence of new LMW sensitizers, which can elicit OA. The immunological mechanism is explained by a type I hypersensitivity reaction in 20% of all newly described LMW agents.

Pubmed
Open Access
Yes
Create date
11/09/2017 17:32
Last modification date
20/08/2019 13:33
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