Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Signaling via vascular endothelial growth factor receptors.
Experimental Cell Research
Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses. The review focuses on the signaling pathways that are initiated from these receptors and the recently identified VEGF coreceptor neuroplilin-1.
Endothelium, Vascular/physiology, Gene Expression Regulation, Neovascularization, Pathologic, Neovascularization, Physiologic, Nerve Tissue Proteins/metabolism, Neuropilin-1, Receptor Protein-Tyrosine Kinases/metabolism, Receptors, Growth Factor/metabolism, Receptors, Vascular Endothelial Growth Factor, Signal Transduction
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