Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0B06832BCD28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer.
Journal
Cancers
Author(s)
Desponds E., Croci D., Wosika V., Hadadi N., Fonseca Costa S.S., Ciarloni L., Ongaro M., Zdimerova H., Leblond M.M., Hosseinian Ehrensberger S., Romero P., Verdeil G.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
19/01/2024
Peer-reviewed
Oui
Volume
16
Number
2
Pages
433
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Blood-based biomarkers represent ideal candidates for the development of non-invasive immuno-oncology-based assays. However, to date, no blood biomarker has been validated to predict clinical responses to immunotherapy. In this study, we used next-generation sequencing (RNAseq) on bulk RNA extracted from whole blood and tumor samples in a pre-clinical MIBC mouse model. We aimed to identify biomarkers associated with immunotherapy response and assess the potential application of simple non-invasive blood biomarkers as a therapeutic decision-making assay compared to tissue-based biomarkers. We established that circulating immune cells and the tumor microenvironment (TME) display highly organ-specific transcriptional responses to ICIs. Interestingly, in both, a common lymphocytic activation signature can be identified associated with the efficient response to immunotherapy, including a blood-specific CD8+ T cell activation/proliferation signature which predicts the immunotherapy response.
Keywords
bladder cancer, blood biomarkers, immunotherapy
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2024 15:20
Last modification date
13/02/2024 7:23
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