Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer.
Details
Serval ID
serval:BIB_0B06832BCD28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immuno-Transcriptomic Profiling of Blood and Tumor Tissue Identifies Gene Signatures Associated with Immunotherapy Response in Metastatic Bladder Cancer.
Journal
Cancers
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
19/01/2024
Peer-reviewed
Oui
Volume
16
Number
2
Pages
433
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Blood-based biomarkers represent ideal candidates for the development of non-invasive immuno-oncology-based assays. However, to date, no blood biomarker has been validated to predict clinical responses to immunotherapy. In this study, we used next-generation sequencing (RNAseq) on bulk RNA extracted from whole blood and tumor samples in a pre-clinical MIBC mouse model. We aimed to identify biomarkers associated with immunotherapy response and assess the potential application of simple non-invasive blood biomarkers as a therapeutic decision-making assay compared to tissue-based biomarkers. We established that circulating immune cells and the tumor microenvironment (TME) display highly organ-specific transcriptional responses to ICIs. Interestingly, in both, a common lymphocytic activation signature can be identified associated with the efficient response to immunotherapy, including a blood-specific CD8+ T cell activation/proliferation signature which predicts the immunotherapy response.
Keywords
bladder cancer, blood biomarkers, immunotherapy
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2024 15:20
Last modification date
13/02/2024 7:23