Article: article from journal or magazin.
Apport des techniques d'immunohistochimie et d'hybridation in situ dans les affections dues ou associées au virus d'Epstein-Barr [Contribution of immunohistochemistry and in situ hybridization techniques in diseases caused by or associated with Epstein-Barr virus].
Archives D'anatomie et De Cytologie Pathologiques
0242-6498; 0395-501X (Print)
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Epstein-Barr virus is associated with many diseases. Today, the pathologist may study either by immunohistochemistry or in situ hybridization on tissue sections: EBV genome, EBV messenger RNA, EBV latent and replicative proteins. Several technics can be performed on fixed paraffin-embedded tissue to demonstrate the presence of EBV DNA, EBER-1 RNA, LMP-1 protein. Frozen tissues are required for the study of EBNA-2, ZEBRA and replicating proteins expression. The results, obtained during the study of benign and malignant proliferations always or often associated with EBV, such as infectious mononucleosis, Burkitt's lymphomas, AIDS associated lymphomas, lymphoproliferations in immunocompromised patients, Hodgkin's disease, and some epithelial proliferations, are summarized.
Acquired Immunodeficiency Syndrome/complications, Burkitt Lymphoma/complications, Burkitt Lymphoma/diagnosis, DNA, Viral/genetics, Herpesvirus 4, Human/isolation & purification, Hodgkin Disease/diagnosis, Humans, Immunohistochemistry/methods, In Situ Hybridization, Infectious Mononucleosis/diagnosis, Lymphoma/complications, Lymphoma, Non-Hodgkin/diagnosis, Lymphoproliferative Disorders/diagnosis, Nucleic Acid Hybridization/physiology, RNA, Viral/genetics
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