Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Le syndrome antisynthétase: un sous-groupe particulier des myopathies idiopathiques inflammatoires. A propos de trois observations. [Anti-synthetase syndrome: a special subgroup of idiopathic inflammatory myopathies. Apropos of 3 case reports]
Schweizerische Rundschau fur Medizin Praxis
Case Reports English Abstract Journal Article --- Old month value: Apr 16
Anti-synthetase antibodies are found in 20 to 25% of all idiopathic inflammatory myopathies and allow identification of a syndrome associating myositis with interstitial pulmonary disease (50 to 70%), polyarthritis, Raynaud's phenomenon and mechanic's hands. Anti-Jo-1 is the most common anti-synthetase antibody. If anti-Jo-1 is present, interstitial lung disease must be looked for, because this is the most important determinant of the outcome. Treatment with high doses of corticosteroids is required. Immunosuppressive drugs are added in resistant cases or as corticosteroid-sparing agents.
Adult Antibodies, Antinuclear/isolation & purification Cough/etiology Dyspnea/etiology Female Humans Ligases/*antagonists & inhibitors/immunology Male Middle Aged Muscle Weakness/*etiology Polymyositis/*etiology/immunology
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