Article: article from journal or magazin.
Preactivation of B lymphocytes does not enhance mouse mammary tumor virus infection.
Journal of Virology
We investigated whether mouse mammary tumor virus (MMTV) favors preactivated or naive B cells as targets for efficient infection. We have demonstrated previously that MMTV activates B cells upon infection. Here, we show that polyclonal activation of B cells leads instead to lower infection levels and attenuated superantigen-specific T-cell responses in vivo. This indicates that naive small resting B cells are the major targets of MMTV infection and that the activation induced by MMTV is sufficient to allow efficient infection.
Animals, B-Lymphocytes/drug effects, B-Lymphocytes/immunology, DNA, Viral, Lymphocyte Activation, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/physiology, Mice, Mice, Inbred BALB C
Web of science
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