Preactivation of B lymphocytes does not enhance mouse mammary tumor virus infection.
Détails
ID Serval
serval:BIB_07B174E96073
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Preactivation of B lymphocytes does not enhance mouse mammary tumor virus infection.
Périodique
Journal of Virology
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
72
Numéro
9
Pages
7688-7691
Langue
anglais
Résumé
We investigated whether mouse mammary tumor virus (MMTV) favors preactivated or naive B cells as targets for efficient infection. We have demonstrated previously that MMTV activates B cells upon infection. Here, we show that polyclonal activation of B cells leads instead to lower infection levels and attenuated superantigen-specific T-cell responses in vivo. This indicates that naive small resting B cells are the major targets of MMTV infection and that the activation induced by MMTV is sufficient to allow efficient infection.
Mots-clé
Animals, B-Lymphocytes/drug effects, B-Lymphocytes/immunology, DNA, Viral, Lymphocyte Activation, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/physiology, Mice, Mice, Inbred BALB C
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 13:30