Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem
Details
Serval ID
serval:BIB_07570578E311
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem
Title of the conference
29thMeeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec) Amsterdam, The Netherlands, 16th – 18th May 2019
Publication state
Published
Issued date
18/04/2019
Language
english
Abstract
Purpose: We evaluated electroretinographic measurements generated by the RETeval device before and after treatment with intravitreal anti-VEGF injections in eyes with diabetic macular oedema (DMO) associated with mild non-proliferative diabetic retinopathy.
Methods: Seven eyes of 5 patients with type 2 diabetes mellitus treated for DMO by intravitreal ranibizumab injections in Jules Gonin University Eye Hospital in Lausanne, Switzerland. ERGs were recorded with the RETeval system before treatment and 1 month after the 3rd injection. Measurements included responses to photopic flicker and ERG recording according to various protocols including ERGs recorded by sinusoidal light stimulus and the RETeval Specific Diabetic Retinopathy Assessment Protocol.
Results: All patients demonstrated significant improvement of visual acuity and resolution of DMO after treatment. We found a significant shortening of implicit times of ERGs after intravitreal injection of anti-VEGF recorded by sinusoidal light stimulus. The mean implicit time of the flicker ERGs recorded by sinusoidal light stimulus was shortened significantly from 30.2 msec (SD: 0.6) at baseline to a mean of 29 msec (SD:0.76) after the last intravitreal injection (p 0.05; paired t-test).
Additionally, the RETeval Specific Diabetic Retinopathy Assessment Protocol that is designed to aid in the detection of vision threatening diabetic retinopathy including clinically significant macular oedema could detect improvement in 71% of our cases.
Conclusions: In the present study we found a significant shortening of the implicit times after ranibizumab treatment using a sinusoidal light stimulus. It is believed that sinusoidal stimulus is sensitive to inner-retinal function though its significance is not yet clearly elucidated. Additionally, the RETeval specific DR Assessment Protocol could detect improvement in the majority of our cases. The RETeval devise offers a novel, quick and easily accessible method of objective electroretinographic measurements though the significance of its clinical role warrants further studies.
Methods: Seven eyes of 5 patients with type 2 diabetes mellitus treated for DMO by intravitreal ranibizumab injections in Jules Gonin University Eye Hospital in Lausanne, Switzerland. ERGs were recorded with the RETeval system before treatment and 1 month after the 3rd injection. Measurements included responses to photopic flicker and ERG recording according to various protocols including ERGs recorded by sinusoidal light stimulus and the RETeval Specific Diabetic Retinopathy Assessment Protocol.
Results: All patients demonstrated significant improvement of visual acuity and resolution of DMO after treatment. We found a significant shortening of implicit times of ERGs after intravitreal injection of anti-VEGF recorded by sinusoidal light stimulus. The mean implicit time of the flicker ERGs recorded by sinusoidal light stimulus was shortened significantly from 30.2 msec (SD: 0.6) at baseline to a mean of 29 msec (SD:0.76) after the last intravitreal injection (p 0.05; paired t-test).
Additionally, the RETeval Specific Diabetic Retinopathy Assessment Protocol that is designed to aid in the detection of vision threatening diabetic retinopathy including clinically significant macular oedema could detect improvement in 71% of our cases.
Conclusions: In the present study we found a significant shortening of the implicit times after ranibizumab treatment using a sinusoidal light stimulus. It is believed that sinusoidal stimulus is sensitive to inner-retinal function though its significance is not yet clearly elucidated. Additionally, the RETeval specific DR Assessment Protocol could detect improvement in the majority of our cases. The RETeval devise offers a novel, quick and easily accessible method of objective electroretinographic measurements though the significance of its clinical role warrants further studies.
Keywords
Treatment in Patients with Diabetic Macular Oedema
Create date
03/09/2019 8:40
Last modification date
28/02/2020 6:19
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