Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem
Détails
ID Serval
serval:BIB_07570578E311
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem
Titre de la conférence
29thMeeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec) Amsterdam, The Netherlands, 16th – 18th May 2019
Statut éditorial
Publié
Date de publication
18/04/2019
Langue
anglais
Résumé
Purpose: We evaluated electroretinographic measurements generated by the RETeval device before and after treatment with intravitreal anti-VEGF injections in eyes with diabetic macular oedema (DMO) associated with mild non-proliferative diabetic retinopathy.
Methods: Seven eyes of 5 patients with type 2 diabetes mellitus treated for DMO by intravitreal ranibizumab injections in Jules Gonin University Eye Hospital in Lausanne, Switzerland. ERGs were recorded with the RETeval system before treatment and 1 month after the 3rd injection. Measurements included responses to photopic flicker and ERG recording according to various protocols including ERGs recorded by sinusoidal light stimulus and the RETeval Specific Diabetic Retinopathy Assessment Protocol.
Results: All patients demonstrated significant improvement of visual acuity and resolution of DMO after treatment. We found a significant shortening of implicit times of ERGs after intravitreal injection of anti-VEGF recorded by sinusoidal light stimulus. The mean implicit time of the flicker ERGs recorded by sinusoidal light stimulus was shortened significantly from 30.2 msec (SD: 0.6) at baseline to a mean of 29 msec (SD:0.76) after the last intravitreal injection (p 0.05; paired t-test).
Additionally, the RETeval Specific Diabetic Retinopathy Assessment Protocol that is designed to aid in the detection of vision threatening diabetic retinopathy including clinically significant macular oedema could detect improvement in 71% of our cases.
Conclusions: In the present study we found a significant shortening of the implicit times after ranibizumab treatment using a sinusoidal light stimulus. It is believed that sinusoidal stimulus is sensitive to inner-retinal function though its significance is not yet clearly elucidated. Additionally, the RETeval specific DR Assessment Protocol could detect improvement in the majority of our cases. The RETeval devise offers a novel, quick and easily accessible method of objective electroretinographic measurements though the significance of its clinical role warrants further studies.
Methods: Seven eyes of 5 patients with type 2 diabetes mellitus treated for DMO by intravitreal ranibizumab injections in Jules Gonin University Eye Hospital in Lausanne, Switzerland. ERGs were recorded with the RETeval system before treatment and 1 month after the 3rd injection. Measurements included responses to photopic flicker and ERG recording according to various protocols including ERGs recorded by sinusoidal light stimulus and the RETeval Specific Diabetic Retinopathy Assessment Protocol.
Results: All patients demonstrated significant improvement of visual acuity and resolution of DMO after treatment. We found a significant shortening of implicit times of ERGs after intravitreal injection of anti-VEGF recorded by sinusoidal light stimulus. The mean implicit time of the flicker ERGs recorded by sinusoidal light stimulus was shortened significantly from 30.2 msec (SD: 0.6) at baseline to a mean of 29 msec (SD:0.76) after the last intravitreal injection (p 0.05; paired t-test).
Additionally, the RETeval Specific Diabetic Retinopathy Assessment Protocol that is designed to aid in the detection of vision threatening diabetic retinopathy including clinically significant macular oedema could detect improvement in 71% of our cases.
Conclusions: In the present study we found a significant shortening of the implicit times after ranibizumab treatment using a sinusoidal light stimulus. It is believed that sinusoidal stimulus is sensitive to inner-retinal function though its significance is not yet clearly elucidated. Additionally, the RETeval specific DR Assessment Protocol could detect improvement in the majority of our cases. The RETeval devise offers a novel, quick and easily accessible method of objective electroretinographic measurements though the significance of its clinical role warrants further studies.
Mots-clé
Treatment in Patients with Diabetic Macular Oedema
Création de la notice
03/09/2019 8:40
Dernière modification de la notice
28/02/2020 6:19
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