Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis [Toxic epidermal necrolysis]

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_073D8BBA0929
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis [Toxic epidermal necrolysis]
Journal
Revue medicale suisse
Author(s)
Bigliardi P.L., Raffoul W., Berger M.M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
02/05/2007
Peer-reviewed
Oui
Volume
3
Number
109
Pages
1112-1114,1116-1118
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
The toxic epidermal necrolysis (TEN) is an immunologic reaction in the skin with apoptosis of kératinocytes: most cases are reactions against drugs. The main features of this reaction are a separation of the epidermis and erosions of the mucus membranes, associated with a reduction of the general condition with kidney and liver failure. This leads to problems similar to those observed in severely burned patients. The mortality high of patients with TEN can be reduced, if the responsible drug is immediately withdrawn and if the patient is treated in a specialized burns intensive care unit. The medical treatment to stop the chain reaction of apoptosis is still under discussion. Through a case report, this article will focus on the complexity of the treatment of patients with TEN and will point out the importance of a multidisciplinary approach.
Keywords
Diagnosis, Differential, Humans, Male, Middle Aged, Stevens-Johnson Syndrome/classification, Stevens-Johnson Syndrome/diagnosis, Stevens-Johnson Syndrome/therapy
Pubmed
Create date
21/01/2008 18:30
Last modification date
13/08/2024 7:50
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