Signalling functions of alpha-tocopherol in smooth muscle cells

Détails

ID Serval
serval:BIB_04DD37DCEA23
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Signalling functions of alpha-tocopherol in smooth muscle cells
Périodique
International Journal for Vitamin and Nutrition Research
Auteur(s)
Azzi  A., Boscoboinik  D., Clement  S., Ozer  N. K., Ricciarelli  R., Stocker  A., Tasinato  A., Sirikci  O.
ISSN
0300-9831 (Print)
Statut éditorial
Publié
Date de publication
1997
Volume
67
Numéro
5
Pages
343-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Résumé
alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha, but not of the other isoforms, by the inhibitor Go6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.
Mots-clé
Animals Cell Division/drug effects Cells, Cultured Dose-Response Relationship, Drug Enzyme Activation/drug effects Isoenzymes/antagonists & inhibitors/*metabolism Male Muscle, Smooth/cytology/drug effects/*enzymology/metabolism Osmolar Concentration Phosphoprotein Phosphatase/drug effects/*metabolism Phosphorylation Protein Kinase C/antagonists & inhibitors/*metabolism Protein Kinase C-alpha Rabbits *Signal Transduction Tetradecanoylphorbol Acetate/pharmacology Vitamin E/*pharmacology
Pubmed
Web of science
Création de la notice
29/01/2008 9:44
Dernière modification de la notice
03/03/2018 13:23
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