Signalling functions of alpha-tocopherol in smooth muscle cells
Détails
ID Serval
serval:BIB_04DD37DCEA23
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Signalling functions of alpha-tocopherol in smooth muscle cells
Périodique
International Journal for Vitamin and Nutrition Research
ISSN
0300-9831 (Print)
Statut éditorial
Publié
Date de publication
1997
Volume
67
Numéro
5
Pages
343-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Résumé
alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha, but not of the other isoforms, by the inhibitor Go6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.
Mots-clé
Animals
Cell Division/drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Activation/drug effects
Isoenzymes/antagonists & inhibitors/*metabolism
Male
Muscle, Smooth/cytology/drug effects/*enzymology/metabolism
Osmolar Concentration
Phosphoprotein Phosphatase/drug effects/*metabolism
Phosphorylation
Protein Kinase C/antagonists & inhibitors/*metabolism
Protein Kinase C-alpha
Rabbits
*Signal Transduction
Tetradecanoylphorbol Acetate/pharmacology
Vitamin E/*pharmacology
Pubmed
Web of science
Création de la notice
29/01/2008 9:44
Dernière modification de la notice
20/08/2019 13:26