Supercooling: A Promising Technique for Prolonged Organ Preservation in Solid Organ Transplantation, and Early Perspectives in Vascularized Composite Allografts.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_040E3495A61F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Supercooling: A Promising Technique for Prolonged Organ Preservation in Solid Organ Transplantation, and Early Perspectives in Vascularized Composite Allografts.
Journal
Frontiers in transplantation
Author(s)
Berkane Y., Hayau J., von Reiterdank I.F., Kharga A., Charlès L., van der Molen A.M., Coert J.H., Bertheuil N., Randolph M., Cetrulo C.L., Longchamp A., Lellouch A.G., Uygun K.
ISSN
2813-2440 (Electronic)
ISSN-L
2813-2440
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
2
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Ex-vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or sub-physiological conditions until transplantation. Alternatively, supercooling techniques involving static preservation at negative temperatures while avoiding ice formation have shown encouraging results in solid organs. Here, the rationale is to decrease the organ's metabolism and need for oxygen and nutrients, allowing for extended preservation durations. The aim of this work is to review all advances of supercooling in transplantation, browsing the literature for each organ. A specific objective was also to study the initial evidence, the prospects, and potential applications of supercooling preservation in Vascularized Composite Allotransplantation (VCA). This complex entity needs a substantial effort to improve long-term outcomes, marked by chronic rejection. Improving preservation techniques is critical to ensure the favorable evolution of VCAs, and supercooling techniques could greatly participate in these advances.
Keywords
Machine Perfusion, Organ preservation, Subzero, Supercooling, VCA, Vascularized Composite Allotransplantation
Pubmed
Open Access
Yes
Create date
06/05/2024 12:03
Last modification date
07/05/2024 7:18
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