Supercooling: A Promising Technique for Prolonged Organ Preservation in Solid Organ Transplantation, and Early Perspectives in Vascularized Composite Allografts.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_040E3495A61F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Supercooling: A Promising Technique for Prolonged Organ Preservation in Solid Organ Transplantation, and Early Perspectives in Vascularized Composite Allografts.
Périodique
Frontiers in transplantation
Auteur⸱e⸱s
Berkane Y., Hayau J., von Reiterdank I.F., Kharga A., Charlès L., van der Molen A.M., Coert J.H., Bertheuil N., Randolph M., Cetrulo C.L., Longchamp A., Lellouch A.G., Uygun K.
ISSN
2813-2440 (Electronic)
ISSN-L
2813-2440
Statut éditorial
Publié
Date de publication
2023
Peer-reviewed
Oui
Volume
2
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Ex-vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or sub-physiological conditions until transplantation. Alternatively, supercooling techniques involving static preservation at negative temperatures while avoiding ice formation have shown encouraging results in solid organs. Here, the rationale is to decrease the organ's metabolism and need for oxygen and nutrients, allowing for extended preservation durations. The aim of this work is to review all advances of supercooling in transplantation, browsing the literature for each organ. A specific objective was also to study the initial evidence, the prospects, and potential applications of supercooling preservation in Vascularized Composite Allotransplantation (VCA). This complex entity needs a substantial effort to improve long-term outcomes, marked by chronic rejection. Improving preservation techniques is critical to ensure the favorable evolution of VCAs, and supercooling techniques could greatly participate in these advances.
Mots-clé
Machine Perfusion, Organ preservation, Subzero, Supercooling, VCA, Vascularized Composite Allotransplantation
Pubmed
Open Access
Oui
Création de la notice
06/05/2024 12:03
Dernière modification de la notice
07/05/2024 7:18
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