Tracking the source of cerebellar epilepsy: hemifacial seizures associated with cerebellar cortical dysplasia.

Details

Serval ID
serval:BIB_03D6E2F5E350
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Tracking the source of cerebellar epilepsy: hemifacial seizures associated with cerebellar cortical dysplasia.
Journal
Epilepsy Research
Author(s)
Lascano A.M., Lemkaddem A., Granziera C., Korff C.M., Boex C., Jenny B., Schmitt-Mechelke T., Thiran J.P., Garibotto V., Vargas M.I., Schaller K., Seeck M., Vulliemoz S.
ISSN
1872-6844 (Electronic)
ISSN-L
0920-1211
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
105
Number
1-2
Pages
245-249
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Traditionally, subcortical structures such as the cerebellum are supposed to exert a modulatory effect on epileptic seizures, rather than being the primary seizure generator. We report a 14-month old girl presenting, since birth, with seizures symptomatic of a right cerebellar dysplasia, manifested as paroxystic contralateral hemifacial spasm and ipsilateral facial weakness. Multimodal imaging was used to investigate both anatomical landmarks related to the cerebellar lesion and mechanisms underlying seizure generation. Electric source imaging (ESI) supported the hypothesis of a right cerebellar epileptogenic generator in concordance with nuclear imaging findings; subsequently validated by intra-operative intralesional recordings. Diffusion spectrum imaging-related tractography (DSI) showed severe cerebellar structural abnormalities confirmed by histological examination. We suggest that hemispheric cerebellar lesions in cases like this are likely to cause epilepsy via an effect on the facial nuclei through ipsilateral and contralateral aberrant connections.
Pubmed
Web of science
Create date
18/08/2013 8:22
Last modification date
20/08/2019 12:25
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