MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_034376670B5D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon.
Périodique
Journal of Evolutionary Biology
Auteur(s)
Gangoso L., Grande J.M., Ducrest A.L., Figuerola J., Bortolotti G.R., Andrés J.A., Roulin A.
ISSN
1420-9101 (Electronic)
ISSN-L
1010-061X
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
24
Numéro
9
Pages
2055-2063
Langue
anglais
Résumé
Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
Mots-clé
Animals, Animals, Newborn, Body Weight, Falconiformes/genetics, Falconiformes/immunology, Female, Genotype, Immunity, Cellular, Male, Phenotype, Phytohemagglutinins, Pigmentation/genetics, Pigmentation/immunology, Receptor, Melanocortin, Type 1/genetics, Receptor, Melanocortin, Type 1/immunology, Sequence Deletion
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/05/2011 16:23
Dernière modification de la notice
20/08/2019 12:25
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