Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.

Details

Serval ID
serval:BIB_02E3BE15E976
Type
Article: article from journal or magazin.
Collection
Publications
Title
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.
Journal
The Journal of neuroscience
Author(s)
Jessberger S., Zhao C., Toni N., Clemenson G.D., Li Y., Gage F.H.
ISSN
1529-2401[electronic]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
27
Number
35
Pages
9400-9407
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.
Keywords
Animals, Behavior, Animal, Cell Proliferation/drug effects, Dendritic Spines/metabolism, Dendritic Spines/pathology, Female, Genetic Vectors/physiology, Green Fluorescent Proteins/metabolism, Hippocampus/pathology, Kainic Acid, Male, Microscopy, Electron, Transmission/methods, Microtubule-Associated Proteins/metabolism, Neurons/metabolism, Neurons/physiology, Neuropeptides/metabolism, Organogenesis, Proto-Oncogene Proteins c-fos/metabolism, Rats, Rats, Inbred F344, Retroviridae/physiology, Seizures/chemically induced, Seizures/pathology, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2010 7:46
Last modification date
20/08/2019 12:25
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