Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.

Détails

ID Serval
serval:BIB_02E3BE15E976
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.
Périodique
The Journal of neuroscience
Auteur⸱e⸱s
Jessberger S., Zhao C., Toni N., Clemenson G.D., Li Y., Gage F.H.
ISSN
1529-2401[electronic]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
27
Numéro
35
Pages
9400-9407
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.
Mots-clé
Animals, Behavior, Animal, Cell Proliferation/drug effects, Dendritic Spines/metabolism, Dendritic Spines/pathology, Female, Genetic Vectors/physiology, Green Fluorescent Proteins/metabolism, Hippocampus/pathology, Kainic Acid, Male, Microscopy, Electron, Transmission/methods, Microtubule-Associated Proteins/metabolism, Neurons/metabolism, Neurons/physiology, Neuropeptides/metabolism, Organogenesis, Proto-Oncogene Proteins c-fos/metabolism, Rats, Rats, Inbred F344, Retroviridae/physiology, Seizures/chemically induced, Seizures/pathology, Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2010 7:46
Dernière modification de la notice
20/08/2019 12:25
Données d'usage