Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Side effects of genome structural changes.
Current Opinion in Genetics and Development
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
Genetic Variation, Genome, Human, Humans, Polymorphism, Single Nucleotide/genetics, Sequence Analysis, DNA, Transcription, Genetic
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