Side effects of genome structural changes.
Détails
ID Serval
serval:BIB_014762682E1E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Side effects of genome structural changes.
Périodique
Current Opinion in Genetics and Development
ISSN
0959-437X[print], 0959-437X[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
17
Numéro
5
Pages
381-386
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
Mots-clé
Genetic Variation, Genome, Human, Humans, Polymorphism, Single Nucleotide/genetics, Sequence Analysis, DNA, Transcription, Genetic
Pubmed
Web of science
Création de la notice
24/01/2008 16:52
Dernière modification de la notice
20/08/2019 13:23