Side effects of genome structural changes.

Details

Serval ID
serval:BIB_014762682E1E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Side effects of genome structural changes.
Journal
Current Opinion in Genetics and Development
Author(s)
Reymond A., Henrichsen C.N., Harewood L., Merla G.
ISSN
0959-437X[print], 0959-437X[linking]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
17
Number
5
Pages
381-386
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
Keywords
Genetic Variation, Genome, Human, Humans, Polymorphism, Single Nucleotide/genetics, Sequence Analysis, DNA, Transcription, Genetic
Pubmed
Web of science
Create date
24/01/2008 15:52
Last modification date
20/08/2019 12:23
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