Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.

Details

Serval ID
serval:BIB_01434BB9E9EB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.
Journal
Medical physics
Author(s)
Schüler E., Acharya M., Montay-Gruel P., Loo B.W., Vozenin M.C., Maxim P.G.
ISSN
2473-4209 (Electronic)
ISSN-L
0094-2405
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
49
Number
3
Pages
2082-2095
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to describe ultra-high-dose rate irradiation with dose rates greater than 40 Gy/s, which results in delivery times of fractions of a second. The experiments presented in that paper were performed with a high-dose-per-pulse 4.5 MeV electron beam, and the results served as the basis for the modern-day field of FLASH radiation therapy (RT). In this article, we review the studies that have been published after those early experiments, demonstrating the robust effects of FLASH RT on normal tissue sparing in preclinical models. We also outline the various irradiation parameters that have been used. Although the robustness of the biological response has been established, the mechanisms behind the FLASH effect are currently under investigation in a number of laboratories. However, differences in the magnitude of the FLASH effect between experiments in different labs have been reported. Reasons for these differences even within the same animal model are currently unknown, but likely has to do with the marked differences in irradiation parameter settings used. Here, we show that these parameters are often not reported, which complicates large multistudy comparisons. For this reason, we propose a new standard for beam parameter reporting and discuss a systematic path to the clinical translation of FLASH RT.
Keywords
Animals, Clinical Protocols, Electrons, Radiotherapy/methods, Radiotherapy Dosage, FLASH effect, biological effects, dosimetry, electron FLASH, reporting system
Pubmed
Web of science
Create date
17/01/2022 11:37
Last modification date
02/11/2022 6:41
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