Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.

Détails

ID Serval
serval:BIB_01434BB9E9EB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.
Périodique
Medical physics
Auteur⸱e⸱s
Schüler E., Acharya M., Montay-Gruel P., Loo B.W., Vozenin M.C., Maxim P.G.
ISSN
2473-4209 (Electronic)
ISSN-L
0094-2405
Statut éditorial
Publié
Date de publication
03/2022
Peer-reviewed
Oui
Volume
49
Numéro
3
Pages
2082-2095
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to describe ultra-high-dose rate irradiation with dose rates greater than 40 Gy/s, which results in delivery times of fractions of a second. The experiments presented in that paper were performed with a high-dose-per-pulse 4.5 MeV electron beam, and the results served as the basis for the modern-day field of FLASH radiation therapy (RT). In this article, we review the studies that have been published after those early experiments, demonstrating the robust effects of FLASH RT on normal tissue sparing in preclinical models. We also outline the various irradiation parameters that have been used. Although the robustness of the biological response has been established, the mechanisms behind the FLASH effect are currently under investigation in a number of laboratories. However, differences in the magnitude of the FLASH effect between experiments in different labs have been reported. Reasons for these differences even within the same animal model are currently unknown, but likely has to do with the marked differences in irradiation parameter settings used. Here, we show that these parameters are often not reported, which complicates large multistudy comparisons. For this reason, we propose a new standard for beam parameter reporting and discuss a systematic path to the clinical translation of FLASH RT.
Mots-clé
Animals, Clinical Protocols, Electrons, Radiotherapy/methods, Radiotherapy Dosage, FLASH effect, biological effects, dosimetry, electron FLASH, reporting system
Pubmed
Web of science
Création de la notice
17/01/2022 11:37
Dernière modification de la notice
02/11/2022 6:41
Données d'usage