Article: article from journal or magazin.
In vivo effects of angiotensin antagonists on plasma aldosterone in the dog
European Journal of Pharmacology
Journal Article --- Old month value: Dec
The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.
Adrenal Cortex Hormones/blood Aldosterone/*blood Angiotensin II/analogs & derivatives/*antagonists & inhibitors/pharmacology Animals Blood Pressure/drug effects Dogs Potassium/blood Renin/blood Saralasin/pharmacology Sodium/blood
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