In vivo effects of angiotensin antagonists on plasma aldosterone in the dog

Détails

ID Serval
serval:BIB_00E4A8C9E8EA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
In vivo effects of angiotensin antagonists on plasma aldosterone in the dog
Périodique
European Journal of Pharmacology
Auteur(s)
Beckerhoff  R., Uhlschmid  G., Furrer  J., Nussberger  J., Schmied  U. R., Vetter  W. J., Siegenthaler  W.
ISSN
0014-2999 (Print)
Statut éditorial
Publié
Date de publication
12/1975
Volume
34
Numéro
2
Pages
363-7
Notes
Journal Article --- Old month value: Dec
Résumé
The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.
Mots-clé
Adrenal Cortex Hormones/blood Aldosterone/*blood Angiotensin II/analogs & derivatives/*antagonists & inhibitors/pharmacology Animals Blood Pressure/drug effects Dogs Potassium/blood Renin/blood Saralasin/pharmacology Sodium/blood
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
20/08/2019 13:23
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