In vivo effects of angiotensin antagonists on plasma aldosterone in the dog

Details

Serval ID
serval:BIB_00E4A8C9E8EA
Type
Article: article from journal or magazin.
Collection
Publications
Title
In vivo effects of angiotensin antagonists on plasma aldosterone in the dog
Journal
European Journal of Pharmacology
Author(s)
Beckerhoff  R., Uhlschmid  G., Furrer  J., Nussberger  J., Schmied  U. R., Vetter  W. J., Siegenthaler  W.
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
12/1975
Volume
34
Number
2
Pages
363-7
Notes
Journal Article --- Old month value: Dec
Abstract
The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.
Keywords
Adrenal Cortex Hormones/blood Aldosterone/*blood Angiotensin II/analogs & derivatives/*antagonists & inhibitors/pharmacology Animals Blood Pressure/drug effects Dogs Potassium/blood Renin/blood Saralasin/pharmacology Sodium/blood
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 12:23
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