In vivo effects of angiotensin antagonists on plasma aldosterone in the dog
Details
Serval ID
serval:BIB_00E4A8C9E8EA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vivo effects of angiotensin antagonists on plasma aldosterone in the dog
Journal
European Journal of Pharmacology
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
12/1975
Volume
34
Number
2
Pages
363-7
Notes
Journal Article --- Old month value: Dec
Abstract
The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.
Keywords
Adrenal Cortex Hormones/blood
Aldosterone/*blood
Angiotensin II/analogs & derivatives/*antagonists &
inhibitors/pharmacology
Animals
Blood Pressure/drug effects
Dogs
Potassium/blood
Renin/blood
Saralasin/pharmacology
Sodium/blood
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 13:23