Confronting the hidden face of progesterone during the follicular phase

Details

Serval ID
serval:BIB_00DB4A38B332
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Confronting the hidden face of progesterone during the follicular phase
Journal
Journal of Assisted Reproduction and Genetics
Author(s)
de Ziegler  D., Brioschi  P. A., Fanchin  R., Bulletti  C.
ISSN
1058-0468
Publication state
Published
Issued date
01/2003
Peer-reviewed
Oui
Volume
20
Number
1
Pages
29-32
Notes
Comment
Editorial
Review --- Old month value: Jan
Abstract
Sporadic cases of late follicular phase progesterone elevation have been described in ART cycles despite routine blockage of endogenous gonadotropins with GnRH agonists, the mechanism of which has been eluding our scrutiny. In this issue of JARG, Levran et al. report the first cases of adult-onset mild form of congenital adrenal hyperplasia (CAH) linked to a deficit in 17-hydorixyloase (17-OH ase). Contrary to CAH due to deficit 21-OH ase, these not only affect the adrenals but also the FSH driven production of E2 and androgen by the ovary thereby leading to progesterone "accumulation" during the follicular phase. Levran's findings offer new hypotheses for explaining the cases late follicular progesterone elevation particularly, when encountered in COH cycles associated with poor E2 elevation. And more importantly, Levran's findings offer new possible options for minimizing their consequences on ART outcome.
Keywords
Adrenal Hyperplasia, Congenital/*physiopathology Female Follicular Phase/*physiology Humans Progesterone/metabolism/*physiology Superovulation/*physiology
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 12:23
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