Confronting the hidden face of progesterone during the follicular phase

Détails

ID Serval
serval:BIB_00DB4A38B332
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Confronting the hidden face of progesterone during the follicular phase
Périodique
Journal of Assisted Reproduction and Genetics
Auteur(s)
de Ziegler  D., Brioschi  P. A., Fanchin  R., Bulletti  C.
ISSN
1058-0468
Statut éditorial
Publié
Date de publication
01/2003
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
29-32
Notes
Comment
Editorial
Review --- Old month value: Jan
Résumé
Sporadic cases of late follicular phase progesterone elevation have been described in ART cycles despite routine blockage of endogenous gonadotropins with GnRH agonists, the mechanism of which has been eluding our scrutiny. In this issue of JARG, Levran et al. report the first cases of adult-onset mild form of congenital adrenal hyperplasia (CAH) linked to a deficit in 17-hydorixyloase (17-OH ase). Contrary to CAH due to deficit 21-OH ase, these not only affect the adrenals but also the FSH driven production of E2 and androgen by the ovary thereby leading to progesterone "accumulation" during the follicular phase. Levran's findings offer new hypotheses for explaining the cases late follicular progesterone elevation particularly, when encountered in COH cycles associated with poor E2 elevation. And more importantly, Levran's findings offer new possible options for minimizing their consequences on ART outcome.
Mots-clé
Adrenal Hyperplasia, Congenital/*physiopathology Female Follicular Phase/*physiology Humans Progesterone/metabolism/*physiology Superovulation/*physiology
Pubmed
Web of science
Création de la notice
28/02/2008 11:37
Dernière modification de la notice
20/08/2019 12:23
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