Uncovering hidden in vivo resonances using editing based on localized TOCSY.

Details

Serval ID
serval:BIB_00904D21C05D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Uncovering hidden in vivo resonances using editing based on localized TOCSY.
Journal
Magnetic Resonance in Medicine
Author(s)
Marjanska M., Henry P.G., Bolan P.J., Vaughan B., Seaquist E.R., Gruetter R., Uğurbil K., Garwood M.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Publication state
Published
Issued date
2005
Volume
53
Number
4
Pages
783-789
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of beta-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.
Keywords
Animals, Brain/metabolism, Brain Chemistry, Glucose/metabolism, Humans, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Signal Processing, Computer-Assisted
Pubmed
Web of science
Create date
04/08/2010 16:28
Last modification date
20/08/2019 13:22
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