Article: article from journal or magazin.
Uncovering hidden in vivo resonances using editing based on localized TOCSY.
Magnetic Resonance in Medicine
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of beta-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.
Animals, Brain/metabolism, Brain Chemistry, Glucose/metabolism, Humans, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Signal Processing, Computer-Assisted
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