Uncovering hidden in vivo resonances using editing based on localized TOCSY.

Détails

ID Serval
serval:BIB_00904D21C05D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Uncovering hidden in vivo resonances using editing based on localized TOCSY.
Périodique
Magnetic Resonance in Medicine
Auteur⸱e⸱s
Marjanska M., Henry P.G., Bolan P.J., Vaughan B., Seaquist E.R., Gruetter R., Uğurbil K., Garwood M.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2005
Volume
53
Numéro
4
Pages
783-789
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of beta-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.
Mots-clé
Animals, Brain/metabolism, Brain Chemistry, Glucose/metabolism, Humans, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Signal Processing, Computer-Assisted
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
20/08/2019 13:22
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