Uncovering hidden in vivo resonances using editing based on localized TOCSY.
Détails
ID Serval
serval:BIB_00904D21C05D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Uncovering hidden in vivo resonances using editing based on localized TOCSY.
Périodique
Magnetic Resonance in Medicine
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2005
Volume
53
Numéro
4
Pages
783-789
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of beta-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.
Mots-clé
Animals, Brain/metabolism, Brain Chemistry, Glucose/metabolism, Humans, Lactic Acid/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Signal Processing, Computer-Assisted
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
20/08/2019 13:22