Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Zillikens, M.C.; Demissie, S.; Hsu, Y.H.; Yerges-Armstrong, L.M.; Chou, W.C.; Stolk, L.; Livshits, G.; Broer, L.; Johnson, T.; Koller, D.L.; Kutalik, Z.; Luan, J.; Malkin, I.; Ried, J.S.; Smith, A.V.; Thorleifsson, G.; Vandenput, L.; Hua Zhao, J.; Zhang, W.; Aghdassi, A.; Åkesson, K.; Amin, N.; Baier, L.J.; Barroso, I.; Bennett, D.A.; Bertram, L.; Biffar, R.; Bochud, M.; Boehnke, M.; Borecki, I.B.; Buchman, A.S.; Byberg, L.; Campbell, H.; Campos Obanda, N.; Cauley, J.A.; Cawthon, P.M.; Cederberg, H.; Chen, Z.; Cho, N.H.; Jin Choi, H.; Claussnitzer, M.; Collins, F.; Cummings, S.R.; De Jager, P.L.; Demuth, I.; Dhonukshe-Rutten, RAM; Diatchenko, L.; Eiriksdottir, G.; Enneman, A.W.; Erdos, M.; Eriksson, J.G.; Eriksson, J.; Estrada, K.; Evans, D.S.; Feitosa, M.F.; Fu, M.; Garcia, M.; Gieger, C.; Girke, T.; Glazer, N.L.; Grallert, H.; Grewal, J.; Han, B.G.; Hanson, R.L.; Hayward, C.; Hofman, A.; Hoffman, E.P.; Homuth, G.; Hsueh, W.C.; Hubal, M.J.; Hubbard, A.; Huffman, K.M.; Husted, L.B.; Illig, T.; Ingelsson, E.; Ittermann, T.; Jansson, J.O.; Jordan, J.M.; Jula, A.; Karlsson, M.; Khaw, K.T.; Kilpeläinen, T.O.; Klopp, N.; Kloth, JSL; Koistinen, H.A.; Kraus, W.E.; Kritchevsky, S.; Kuulasmaa, T.; Kuusisto, J.; Laakso, M.; Lahti, J.; Lang, T.; Langdahl, B.L.; Launer, L.J.; Lee, J.Y.; Lerch, M.M.; Lewis, J.R.; Lind, L.; Lindgren, C.; Liu, Y.; Liu, T.; Liu, Y.; Ljunggren, Ö.; Lorentzon, M.; Luben, R.N.; Maixner, W.; McGuigan, F.E.; Medina-Gomez, C.; Meitinger, T.; Melhus, H.; Mellström, D.; Melov, S.; Michaëlsson, K.; Mitchell, B.D.; Morris, A.P.; Mosekilde, L.; Newman, A.; Nielson, C.M.; O'Connell, J.R.; Oostra, B.A.; Orwoll, E.S.; Palotie, A.; Parker, S.; Peacock, M.; Perola, M.; Peters, A.; Polasek, O.; Prince, R.L.; Räikkönen, K.; Ralston, S.H.; Ripatti, S.; Robbins, J.A.; Rotter, J.I.; Rudan, I.; Salomaa, V.; Satterfield, S.; Schadt, E.E.; Schipf, S.; Scott, L.; Sehmi, J.; Shen, J.; Soo Shin, C.; Sigurdsson, G.; Smith, S.; Soranzo, N.; Stančáková, A.; Steinhagen-Thiessen, E.; Streeten, E.A.; Styrkarsdottir, U.; Swart, KMA; Tan, S.T.; Tarnopolsky, M.A.; Thompson, P.; Thomson, C.A.; Thorsteinsdottir, U.; Tikkanen, E.; Tranah, G.J.; Tuomilehto, J.; van Schoor, N.M.; Verma, A.; Vollenweider, P.; Völzke, H.; Wactawski-Wende, J.; Walker, M.; Weedon, M.N.; Welch, R.; Wichmann, H.E.; Widen, E.; Williams, FMK; Wilson, J.F.; Wright, N.C.; Xie, W.; Yu, L.; Zhou, Y.; Chambers, J.C.; Döring, A.; van Duijn, C.M.; Econs, M.J.; Gudnason, V.; Kooner, J.S.; Psaty, B.M.; Spector, T.D.; Stefansson, K.; Rivadeneira, F.; Uitterlinden, A.G.; Wareham, N.J.; Ossowski, V.; Waterworth, D.; Loos, RJF; Karasik, D.; Harris, T.B.; Ohlsson, C.; Kiel, D.P.

doi:10.1038/s41467-017-00031-7

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

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Download: BIB_0059C1D3A0A7.pdf (354.50 [Ko])
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Version: Final published version

Serval ID

serval:BIB_0059C1D3A0A7

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Journal

Nature communications

Author(s)

Zillikens M.C., Demissie S., Hsu Y.H., Yerges-Armstrong L.M., Chou W.C., Stolk L., Livshits G., Broer L., Johnson T., Koller D.L., Kutalik Z., Luan J., Malkin I., Ried J.S., Smith A.V., Thorleifsson G., Vandenput L., Hua Zhao J., Zhang W., Aghdassi A., Åkesson K., Amin N., Baier L.J., Barroso I., Bennett D.A., Bertram L., Biffar R., Bochud M., Boehnke M., Borecki I.B., Buchman A.S., Byberg L., Campbell H., Campos Obanda N., Cauley J.A., Cawthon P.M., Cederberg H., Chen Z., Cho N.H., Jin Choi H., Claussnitzer M., Collins F., Cummings S.R., De Jager P.L., Demuth I., Dhonukshe-Rutten RAM, Diatchenko L., Eiriksdottir G., Enneman A.W., Erdos M., Eriksson J.G., Eriksson J., Estrada K., Evans D.S., Feitosa M.F., Fu M., Garcia M., Gieger C., Girke T., Glazer N.L., Grallert H., Grewal J., Han B.G., Hanson R.L., Hayward C., Hofman A., Hoffman E.P., Homuth G., Hsueh W.C., Hubal M.J., Hubbard A., Huffman K.M., Husted L.B., Illig T., Ingelsson E., Ittermann T., Jansson J.O., Jordan J.M., Jula A., Karlsson M., Khaw K.T., Kilpeläinen T.O., Klopp N., Kloth JSL, Koistinen H.A., Kraus W.E., Kritchevsky S., Kuulasmaa T., Kuusisto J., Laakso M., Lahti J., Lang T., Langdahl B.L., Launer L.J., Lee J.Y., Lerch M.M., Lewis J.R., Lind L., Lindgren C., Liu Y., Liu T., Liu Y., Ljunggren Ö., Lorentzon M., Luben R.N., Maixner W., McGuigan F.E., Medina-Gomez C., Meitinger T., Melhus H., Mellström D., Melov S., Michaëlsson K., Mitchell B.D., Morris A.P., Mosekilde L., Newman A., Nielson C.M., O'Connell J.R., Oostra B.A., Orwoll E.S., Palotie A., Parker S., Peacock M., Perola M., Peters A., Polasek O., Prince R.L., Räikkönen K., Ralston S.H., Ripatti S., Robbins J.A., Rotter J.I., Rudan I., Salomaa V., Satterfield S., Schadt E.E., Schipf S., Scott L., Sehmi J., Shen J., Soo Shin C., Sigurdsson G., Smith S., Soranzo N., Stančáková A., Steinhagen-Thiessen E., Streeten E.A., Styrkarsdottir U., Swart KMA, Tan S.T., Tarnopolsky M.A., Thompson P., Thomson C.A., Thorsteinsdottir U., Tikkanen E., Tranah G.J., Tuomilehto J., van Schoor N.M., Verma A., Vollenweider P., Völzke H., Wactawski-Wende J., Walker M., Weedon M.N., Welch R., Wichmann H.E., Widen E., Williams FMK, Wilson J.F., Wright N.C., Xie W., Yu L., Zhou Y., Chambers J.C., Döring A., van Duijn C.M., Econs M.J., Gudnason V., Kooner J.S., Psaty B.M., Spector T.D., Stefansson K., Rivadeneira F., Uitterlinden A.G., Wareham N.J., Ossowski V., Waterworth D., Loos RJF, Karasik D., Harris T.B., Ohlsson C., Kiel D.P.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

19/07/2017

Peer-reviewed

Oui

Volume

Number

Pages

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

URN

urn:nbn:ch:serval-BIB_0059C1D3A0A79

OAI-PMH

oai:serval.unil.ch:BIB_0059C1D3A0A7

DOI

10.1038/s41467-017-00031-7

Pubmed

28724990

Web of science

000405818900003

Open Access

Yes