Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Détails

Ressource 1Télécharger: BIB_0059C1D3A0A7.pdf (354.50 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0059C1D3A0A7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Périodique
Nature communications
Auteur(s)
Zillikens M.C., Demissie S., Hsu Y.H., Yerges-Armstrong L.M., Chou W.C., Stolk L., Livshits G., Broer L., Johnson T., Koller D.L., Kutalik Z., Luan J., Malkin I., Ried J.S., Smith A.V., Thorleifsson G., Vandenput L., Hua Zhao J., Zhang W., Aghdassi A., Åkesson K., Amin N., Baier L.J., Barroso I., Bennett D.A., Bertram L., Biffar R., Bochud M., Boehnke M., Borecki I.B., Buchman A.S., Byberg L., Campbell H., Campos Obanda N., Cauley J.A., Cawthon P.M., Cederberg H., Chen Z., Cho N.H., Jin Choi H., Claussnitzer M., Collins F., Cummings S.R., De Jager P.L., Demuth I., Dhonukshe-Rutten RAM, Diatchenko L., Eiriksdottir G., Enneman A.W., Erdos M., Eriksson J.G., Eriksson J., Estrada K., Evans D.S., Feitosa M.F., Fu M., Garcia M., Gieger C., Girke T., Glazer N.L., Grallert H., Grewal J., Han B.G., Hanson R.L., Hayward C., Hofman A., Hoffman E.P., Homuth G., Hsueh W.C., Hubal M.J., Hubbard A., Huffman K.M., Husted L.B., Illig T., Ingelsson E., Ittermann T., Jansson J.O., Jordan J.M., Jula A., Karlsson M., Khaw K.T., Kilpeläinen T.O., Klopp N., Kloth JSL, Koistinen H.A., Kraus W.E., Kritchevsky S., Kuulasmaa T., Kuusisto J., Laakso M., Lahti J., Lang T., Langdahl B.L., Launer L.J., Lee J.Y., Lerch M.M., Lewis J.R., Lind L., Lindgren C., Liu Y., Liu T., Liu Y., Ljunggren Ö., Lorentzon M., Luben R.N., Maixner W., McGuigan F.E., Medina-Gomez C., Meitinger T., Melhus H., Mellström D., Melov S., Michaëlsson K., Mitchell B.D., Morris A.P., Mosekilde L., Newman A., Nielson C.M., O'Connell J.R., Oostra B.A., Orwoll E.S., Palotie A., Parker S., Peacock M., Perola M., Peters A., Polasek O., Prince R.L., Räikkönen K., Ralston S.H., Ripatti S., Robbins J.A., Rotter J.I., Rudan I., Salomaa V., Satterfield S., Schadt E.E., Schipf S., Scott L., Sehmi J., Shen J., Soo Shin C., Sigurdsson G., Smith S., Soranzo N., Stančáková A., Steinhagen-Thiessen E., Streeten E.A., Styrkarsdottir U., Swart KMA, Tan S.T., Tarnopolsky M.A., Thompson P., Thomson C.A., Thorsteinsdottir U., Tikkanen E., Tranah G.J., Tuomilehto J., van Schoor N.M., Verma A., Vollenweider P., Völzke H., Wactawski-Wende J., Walker M., Weedon M.N., Welch R., Wichmann H.E., Widen E., Williams FMK, Wilson J.F., Wright N.C., Xie W., Yu L., Zhou Y., Chambers J.C., Döring A., van Duijn C.M., Econs M.J., Gudnason V., Kooner J.S., Psaty B.M., Spector T.D., Stefansson K., Rivadeneira F., Uitterlinden A.G., Wareham N.J., Ossowski V., Waterworth D., Loos RJF, Karasik D., Harris T.B., Ohlsson C., Kiel D.P.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
19/07/2017
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
80
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

Pubmed
Web of science
Open Access
Oui
Création de la notice
03/08/2017 11:02
Dernière modification de la notice
20/08/2019 13:22
Données d'usage