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T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
Animals, Antigens, Surface/genetics, Antigens, Surface/immunology, Immune Tolerance, Major Histocompatibility Complex, Mice, Mice, Inbred Strains, Minor Lymphocyte Stimulatory Antigens, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology, Thymus Gland/immunology
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