T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Details
Serval ID
serval:BIB_004A420E788B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Journal
Nature
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Publication state
Published
Issued date
1988
Volume
332
Number
6159
Pages
40-45
Language
english
Abstract
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
Keywords
Animals, Antigens, Surface/genetics, Antigens, Surface/immunology, Immune Tolerance, Major Histocompatibility Complex, Mice, Mice, Inbred Strains, Minor Lymphocyte Stimulatory Antigens, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology, Thymus Gland/immunology
Pubmed
Web of science
Create date
24/01/2008 15:48
Last modification date
20/08/2019 13:22
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