T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Détails
ID Serval
serval:BIB_004A420E788B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Périodique
Nature
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
1988
Volume
332
Numéro
6159
Pages
40-45
Langue
anglais
Résumé
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
Mots-clé
Animals, Antigens, Surface/genetics, Antigens, Surface/immunology, Immune Tolerance, Major Histocompatibility Complex, Mice, Mice, Inbred Strains, Minor Lymphocyte Stimulatory Antigens, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology, Thymus Gland/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 12:22