TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

Détails

ID Serval
serval:BIB_FDDFF725E09A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
Périodique
Journal of Immunology
Auteur(s)
Van Maele L., Carnoy C., Cayet D., Songhet P., Dumoutier L., Ferrero I., Janot L., Erard F., Bertout J., Leger H., Sebbane F., Benecke A., Renauld J.C., Hardt W.D., Ryffel B., Sirard J.C.
ISSN
1550-6606[electronic], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
185
Numéro
2
Pages
1177-1185
Langue
anglais
Résumé
In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3(neg)CD127(+) immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3(neg)CD127(+) cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.
Mots-clé
Animals, Antigens, CD3/genetics, Antigens, CD3/immunology, Cells, Cultured, Dendritic Cells/drug effects, Dendritic Cells/immunology, Female, Flagellin/pharmacology, Flow Cytometry, Gene Expression/drug effects, Gene Expression/immunology, Ileum/drug effects, Ileum/immunology, Interleukin-17/genetics, Interleukin-17/immunology, Interleukin-7 Receptor alpha Subunit/genetics, Interleukin-7 Receptor alpha Subunit/immunology, Interleukins/genetics, Interleukins/immunology, Lymphoid Tissue/cytology, Lymphoid Tissue/immunology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, SCID, Mice, Transgenic, Mucous Membrane/cytology, Mucous Membrane/immunology, Oligonucleotide Array Sequence Analysis, Signal Transduction/immunology, Spleen/cytology, Spleen/immunology, Toll-Like Receptor 5/genetics, Toll-Like Receptor 5/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/02/2011 10:25
Dernière modification de la notice
20/08/2019 16:28
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