Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?

Détails

ID Serval
serval:BIB_E462AF5D0372
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?
Périodique
American Journal of Pathology
Auteur(s)
Willcox  N., Schluep  M., Ritter  M. A., Schuurman  H. J., Newsom-Davis  J., Christensson  B.
ISSN
0002-9440 (Print)
Statut éditorial
Publié
Date de publication
06/1987
Volume
127
Numéro
3
Pages
447-460
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
The authors report an immunohistologic study of primary thymomas from 23 cases with myasthenia gravis (MG) and 7 without. Typical T6+ cortical thymocytes were usually abundant. Most epithelial cells initially appeared to be of cortical type, too, though many bore subcapsular markers in most samples. However, two-color immunofluorescence revealed unexpected heterogeneity, numerous epithelial cells simultaneously expressing some or all of the markers of both these subsets (even in two pleural metastases). It is inferred that there is a common tumor stem cell whose normal counterpart may be related to the rare patches of similar phenotype in the cortex in control samples. The authors could detect no major differences in 5 of 7 samples from nonmyasthenics; thus, most thymoma cases may risk the development of MG. Finally, thymomas from 6 of 7 further MG cases pretreated with corticosteroids showed very few cortical thymocytes, and the (phenotypically similar) epithelium was more obvious.
Mots-clé
Adult Aged Antibodies, Monoclonal/diagnostic use Antigens, Surface/analysis Epithelium/pathology Fluorescent Antibody Technique Humans Immunosuppression Keratins/metabolism Middle Aged Myasthenia Gravis/complications/*pathology Neoplasm Metastasis T-Lymphocytes/pathology Thymoma/complications/*pathology Thymus Neoplasms/complications/*pathology
Pubmed
Web of science
Création de la notice
25/01/2008 12:46
Dernière modification de la notice
20/08/2019 16:07
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