Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?

Details

Serval ID
serval:BIB_E462AF5D0372
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?
Journal
American Journal of Pathology
Author(s)
Willcox  N., Schluep  M., Ritter  M. A., Schuurman  H. J., Newsom-Davis  J., Christensson  B.
ISSN
0002-9440 (Print)
Publication state
Published
Issued date
06/1987
Volume
127
Number
3
Pages
447-460
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
The authors report an immunohistologic study of primary thymomas from 23 cases with myasthenia gravis (MG) and 7 without. Typical T6+ cortical thymocytes were usually abundant. Most epithelial cells initially appeared to be of cortical type, too, though many bore subcapsular markers in most samples. However, two-color immunofluorescence revealed unexpected heterogeneity, numerous epithelial cells simultaneously expressing some or all of the markers of both these subsets (even in two pleural metastases). It is inferred that there is a common tumor stem cell whose normal counterpart may be related to the rare patches of similar phenotype in the cortex in control samples. The authors could detect no major differences in 5 of 7 samples from nonmyasthenics; thus, most thymoma cases may risk the development of MG. Finally, thymomas from 6 of 7 further MG cases pretreated with corticosteroids showed very few cortical thymocytes, and the (phenotypically similar) epithelium was more obvious.
Keywords
Adult Aged Antibodies, Monoclonal/diagnostic use Antigens, Surface/analysis Epithelium/pathology Fluorescent Antibody Technique Humans Immunosuppression Keratins/metabolism Middle Aged Myasthenia Gravis/complications/*pathology Neoplasm Metastasis T-Lymphocytes/pathology Thymoma/complications/*pathology Thymus Neoplasms/complications/*pathology
Pubmed
Web of science
Create date
25/01/2008 12:46
Last modification date
20/08/2019 16:07
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