Article: article from journal or magazin.
Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?
American Journal of Pathology
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun
The authors report an immunohistologic study of primary thymomas from 23 cases with myasthenia gravis (MG) and 7 without. Typical T6+ cortical thymocytes were usually abundant. Most epithelial cells initially appeared to be of cortical type, too, though many bore subcapsular markers in most samples. However, two-color immunofluorescence revealed unexpected heterogeneity, numerous epithelial cells simultaneously expressing some or all of the markers of both these subsets (even in two pleural metastases). It is inferred that there is a common tumor stem cell whose normal counterpart may be related to the rare patches of similar phenotype in the cortex in control samples. The authors could detect no major differences in 5 of 7 samples from nonmyasthenics; thus, most thymoma cases may risk the development of MG. Finally, thymomas from 6 of 7 further MG cases pretreated with corticosteroids showed very few cortical thymocytes, and the (phenotypically similar) epithelium was more obvious.
Adult Aged Antibodies, Monoclonal/diagnostic use Antigens, Surface/analysis Epithelium/pathology Fluorescent Antibody Technique Humans Immunosuppression Keratins/metabolism Middle Aged Myasthenia Gravis/complications/*pathology Neoplasm Metastasis T-Lymphocytes/pathology Thymoma/complications/*pathology Thymus Neoplasms/complications/*pathology
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