Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.

Détails

Ressource 1Télécharger: Brandt, Single-Cell analysis in HIV, Ann Rev Virol 2020.pdf (2586.90 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_DB4C338CA91C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.
Périodique
Annual review of virology
Auteur⸱e⸱s
Brandt L., Cristinelli S., Ciuffi A.
ISSN
2327-0578 (Electronic)
ISSN-L
2327-056X
Statut éditorial
Publié
Date de publication
29/09/2020
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
333-350
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploited to further understand the complex virus-host interplay. Single-cell technologies applied in the context of human immunodeficiency virus (HIV) infection proved to be valuable tools to help uncover specific biomarkers as well as novel candidate players in virus-host interactions. This review aims at providing an updated overview of single-cell analyses in the field of HIV and acquired knowledge on HIV infection, latency, and host response. Although HIV is a pioneering example, similar single-cell approaches have proven to be valuable for elucidating the behavior and virus-host interplay in a range of other viruses.
Mots-clé
HIV, heterogeneity, immunity, innate immunity, latency, permissiveness, single-cell
Pubmed
Web of science
Création de la notice
02/10/2020 13:48
Dernière modification de la notice
18/05/2023 7:15
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