Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.

Details

Serval ID
serval:BIB_DB4C338CA91C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.
Journal
Annual review of virology
Author(s)
Brandt L., Cristinelli S., Ciuffi A.
ISSN
2327-0578 (Electronic)
ISSN-L
2327-056X
Publication state
Published
Issued date
29/09/2020
Peer-reviewed
Oui
Volume
7
Number
1
Pages
333-350
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploited to further understand the complex virus-host interplay. Single-cell technologies applied in the context of human immunodeficiency virus (HIV) infection proved to be valuable tools to help uncover specific biomarkers as well as novel candidate players in virus-host interactions. This review aims at providing an updated overview of single-cell analyses in the field of HIV and acquired knowledge on HIV infection, latency, and host response. Although HIV is a pioneering example, similar single-cell approaches have proven to be valuable for elucidating the behavior and virus-host interplay in a range of other viruses.
Keywords
HIV, heterogeneity, immunity, innate immunity, latency, permissiveness, single-cell
Pubmed
Web of science
Create date
02/10/2020 13:48
Last modification date
25/02/2021 7:26
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