Protection against cutaneous leishmaniasis in outbred vervet monkeys using a recombinant histone H1 antigen.

Détails

Ressource 1Télécharger: serval:BIB_CAC86D46812C.P001 (237.84 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_CAC86D46812C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protection against cutaneous leishmaniasis in outbred vervet monkeys using a recombinant histone H1 antigen.
Périodique
Journal of Infectious Diseases
Auteur(s)
Masina S., Gicheru M.M., Demotz S.O., Fasel N.J.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
2003
Volume
188
Numéro
8
Pages
1250-1257
Langue
anglais
Résumé
Infection with Leishmania major parasites results in the development of cutaneous ulcerative lesions on the skin. We investigated the protective potential of a single, recombinant histone H1 antigen against cutaneous leishmaniasis in an outbred population of vervet monkeys, using Montanide adjuvant. Protection was assessed by challenging the animals with a mixture of vector sand fly salivary-gland lysate and a low dose of in vitro-derived parasites, thus more closely mimicking natural infection induced by L. major. The course of infection in immunized monkeys was compared with that of animals that had healed from a primary infection and were immune. The monkeys immunized with recombinant histone H1 showed a reduced development of lesion size, compared with controls. Our study therefore illustrates the potential use of histone H1 as a vaccine candidate against cutaneous leishmaniasis in humans.
Mots-clé
Adjuvants, Immunologic, Animals, Animals, Outbred Strains, Antibodies, Protozoan/blood, Cercopithecus aethiops, Disease Models, Animal, Histones/administration & dosage, Histones/genetics, Humans, Hypersensitivity, Delayed, Leishmania major/pathogenicity, Leishmaniasis, Cutaneous/parasitology, Leishmaniasis, Cutaneous/prevention & control, Protozoan Vaccines/administration & dosage, Protozoan Vaccines/immunology, Psychodidae/parasitology, Recombinant Proteins/administration & dosage, Recombinant Proteins/genetics, Vaccination
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:02
Dernière modification de la notice
25/09/2019 6:10
Données d'usage