Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes
Détails
ID Serval
serval:BIB_BFB8C5543009
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes
Périodique
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Statut éditorial
Publié
Date de publication
04/1996
Volume
173
Numéro
4
Pages
849-56
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Résumé
Initiation of antiretroviral monotherapy early in the course of infection with human immunodeficiency virus may result in a temporary slowing in the rate of disease progression; however, little is known about the virologic effects of early therapy. Virus load was measured in peripheral blood and lymph nodes from 16 antiretroviral-naive patients with a mean CD4 T lymphocyte count of 659 cells/microliter at baseline and after 8 weeks of either no treatment or zidovudine therapy. CD4 T lymphocyte counts and all virologic parameters examined remained unchanged regardless of zidovudine treatment status. Histopathology and virus distribution within lymph nodes remained constant between baseline and week 8 in each patient, indicating that the virologic and histologic parameters examined in a single lymph node are representative of a systemic process. Early antiretroviral monotherapy with zidovudine had no effect on virologic parameters in this group of patients with relatively high CD4 T lymphocyte counts and low measures of virus load at baseline.
Mots-clé
Adult
Antiviral Agents/*therapeutic use
Base Sequence
Biological Markers
CD4 Lymphocyte Count
DNA Primers/chemistry
Female
HIV/*growth & development
HIV Infections/*drug therapy/microbiology
HIV-1 Reverse Transcriptase
Humans
In Situ Hybridization
Lymph Nodes/microbiology
Male
Molecular Sequence Data
RNA-Directed DNA Polymerase/metabolism
Reverse Transcriptase Inhibitors/*therapeutic use
Time Factors
Virus Replication
Zidovudine/*therapeutic use
Pubmed
Web of science
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
20/08/2019 16:34