Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes

Détails

ID Serval
serval:BIB_BFB8C5543009
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes
Périodique
Journal of Infectious Diseases
Auteur(s)
Cohen  O. J., Pantaleo  G., Holodniy  M., Fox  C. H., Orenstein  J. M., Schnittman  S., Niu  M., Graziosi  C., Pavlakis  G. N., Lalezari  J., Bartlett  J. A., Steigbigel  R. T., Cohn  J., Novak  R., McMahon  D., Bilello  J., Fauci  A. S.
ISSN
0022-1899 (Print)
Statut éditorial
Publié
Date de publication
04/1996
Volume
173
Numéro
4
Pages
849-56
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Résumé
Initiation of antiretroviral monotherapy early in the course of infection with human immunodeficiency virus may result in a temporary slowing in the rate of disease progression; however, little is known about the virologic effects of early therapy. Virus load was measured in peripheral blood and lymph nodes from 16 antiretroviral-naive patients with a mean CD4 T lymphocyte count of 659 cells/microliter at baseline and after 8 weeks of either no treatment or zidovudine therapy. CD4 T lymphocyte counts and all virologic parameters examined remained unchanged regardless of zidovudine treatment status. Histopathology and virus distribution within lymph nodes remained constant between baseline and week 8 in each patient, indicating that the virologic and histologic parameters examined in a single lymph node are representative of a systemic process. Early antiretroviral monotherapy with zidovudine had no effect on virologic parameters in this group of patients with relatively high CD4 T lymphocyte counts and low measures of virus load at baseline.
Mots-clé
Adult Antiviral Agents/*therapeutic use Base Sequence Biological Markers CD4 Lymphocyte Count DNA Primers/chemistry Female HIV/*growth & development HIV Infections/*drug therapy/microbiology HIV-1 Reverse Transcriptase Humans In Situ Hybridization Lymph Nodes/microbiology Male Molecular Sequence Data RNA-Directed DNA Polymerase/metabolism Reverse Transcriptase Inhibitors/*therapeutic use Time Factors Virus Replication Zidovudine/*therapeutic use
Pubmed
Web of science
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
03/03/2018 21:04
Données d'usage